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Develop a world first CAR T-cell therapy for cutaneous T cell lymphoma

Develop a world first CAR T-cell therapy for cutaneous T cell lymphoma

Develop a world first CAR T-cell therapy for cutaneous T cell lymphoma

Project Details

CAR-T treatments have not yet been globally trialled for use in T-cell lymphoma, due to the difficulty in identifying a protein that is unique to the T-cell malignancy, but not present on the patients’ own normal T-cells. The Hudson Medical Research Institute have been conducting preliminary laboratory experiments looking at a protein called CTH01, which seems to meet this criterion. Preliminary lab data suggest a CAR-T product using this protein can be manufactured in the lab, and is effective in killing skin lymphoma cells in laboratory experiments.

We are supporting research to produce and manufacture this novel CAR-T product at scale, and to then undertake a world-first clinical trial of this cellular product in patients with cutaneous T-cell lymphoma.

Thank you to the Erdi Foundation, Percy Baxter Charitable Trust, Broomhead Family Foundation and anonymous donors for their support.

Three year project of $600,000 is needed (funding is still needed for year 3)
Total Project cost: $600,000
Funding received to date: $530,000
Seeking: $70,000